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KMID : 0390320130230020099
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Chungbuk Medical Journal
2013 Volume.23 No. 2 p.99 ~ p.106
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Korean Black Raspberry (Rubus coreanus) Attenuates Pressure Overload-Induced Cardiac Hypertrophy in Rats
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Kim Chan-Hyung
Ahn Hee-Yul
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Abstract
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Purpose: Pressure overload disease, such as valvular stenosis and systemic hypertension, manifests itself morphologically, in patients, as cardiac concentric hypertrophy. Prevention of cardiac remodelling due to increased pressure overload is important to reduce morbidity and mortality.Epidemiological studies have shown a significant inverse association between flavonoids from natural antioxidants and long-term mortality from coronary heart disease. The dried unripe fruits of Rubus coreanus have been used for the management of impotence, spermatorrhea, enuresis, asthma, allergic diseases but cardiovascular effect remain unclear till date. Therefore, we investigated whether the aqueous extract of Rubus coreanus (RCE) supplementation could lessen in vivo pressure overload-mediated cardiac hypertrophy.
Materials and Methods: Male Sprague Dawley rats were anesthetized and transaortic constriction was created using a 4-0 suture tied twice around the suprarenal aorta. A freshly prepared solution with different kind of flavonoids were administrated orally every day to aortic banded rats over a period of 7 consecutive days.
Results: Cardiac hypertrophy was induced by suprarenal transverse abdominal aortic constriction (AC) in rats. One week after AC surgery, heart to body weight (HW/BW) ratio increased in the AC group by 52% compared with the Sham group. Neither apigenin, lycopene, nor sulforaphane has a significant effect on cardiac hypertrophy. However, RCE administration suppressed the load-induced increase in heart weight by 80%. Despite abolition of hypertrophy by RCE, transstenotic pressure gradients were not changed.
Conclusion: These results suggest that RCE prevents the development of left ventricular concentric hypertrophy by pressure overload and may be a useful therapeutic modality to prevent cardiac remodelling in patients with pressure overload myocardial diseases.
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KEYWORD
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cardiac hypertrophy, Rubus coreanus, pressure overload
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